Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain

by Clinical Neuropsychologist Online | Tuesday, April 9, 2024 | Neuroscience

Nature Neuroscience, Published online: 09 April 2024; doi:10.1038/s41593-024-01616-4RNA alternative splicing is involved in determining cell identity, but a comprehensive molecular map is missing. Here, the authors provide a human and mouse brain atlas of transcript...

Widespread changes in alternative splicing in developing and adult mouse brain

by Clinical Neuropsychologist Online | Tuesday, April 9, 2024 | Neuroscience

Nature Neuroscience, Published online: 09 April 2024; doi:10.1038/s41593-024-01617-3In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age influence the isoform repertoire of cell subtypes. We link peak...

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

by Clinical Neuropsychologist Online | Monday, April 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01615-5Precise profiling of dendritic RNA regulation reveals how neuronal depolarization leads to ribosome switching onto short upstream open reading frames and new coding sequences to...

Pushing the bounds on dimensionality

by Clinical Neuropsychologist Online | Monday, April 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01623-5Pushing the bounds on dimensionality If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post...

HDAC3 stokes microglia in stroke

by Clinical Neuropsychologist Online | Monday, April 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01622-6HDAC3 stokes microglia in stroke If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is...

Restoring sensation to prosthetics

by Clinical Neuropsychologist Online | Monday, April 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01621-7Restoring sensation to prosthetics If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is...