A neuroprotective role of polyunsaturated fatty acids in C9orf72-ALS/FTD

by Clinical Neuropsychologist | Wednesday, March 26, 2025 | Neuroscience

Nature Neuroscience, Published online: 26 March 2025; doi:10.1038/s41593-025-01920-7New research shows that lipid metabolism genes are downregulated in patient samples and Drosophila models of amyotrophic lateral sclerosis or frontotemporal dementia associated with...

Integrating multimodal data to understand cortical circuit architecture and function

by Clinical Neuropsychologist | Monday, March 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 March 2025; doi:10.1038/s41593-025-01904-7This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding...

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks

by Clinical Neuropsychologist | Monday, March 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 March 2025; doi:10.1038/s41593-025-01893-7The temporal order of events in working memory is thought to be reflected by ordered neuronal firing at different phases. Here the authors show that this is not the case and that phase...

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord

by Clinical Neuropsychologist | Monday, March 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 March 2025; doi:10.1038/s41593-025-01921-6Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a...

Author Correction: Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis

by Clinical Neuropsychologist | Friday, March 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 March 2025; doi:10.1038/s41593-025-01941-2Author Correction: Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis If you do not see content above, kindly GO TO SOURCE. Not all publishers...

Synaptic plasticity rules driving representational shifting in the hippocampus

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 March 2025; doi:10.1038/s41593-025-01894-6Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The...