A suite of engineered mice for interrogating psychedelic drug actions

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02375-0Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across...

Neuroligin-3–CSPG4 interaction maintains oligodendrocyte precursor cell progenitor state and promotes glioma proliferation through mechanotransduction

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02397-8This study finds that shed NLGN3 interacts with the glycosylated surface protein CSPG4 on both normal and malignant glial cells, activating mechanotransduction pathways that drive...

Comparative insights into insula structure and function

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02380-3Charbonneau et al. compare how the insula is structured and functions in humans, monkeys and rodents, revealing similarities and differences across species that are likely to impact...

Norepinephrine and dopamine sensor crosstalk depends on local innervation density

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Neuroscience

Nature Neuroscience, Published online: 05 August 2026; doi:10.1038/s41593-026-02379-wThis study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and...

Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Neuroscience

Nature Neuroscience, Published online: 05 August 2026; doi:10.1038/s41593-026-02388-9The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward...

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes

by Clinical Neuropsychologist Online | Tuesday, August 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 August 2026; doi:10.1038/s41593-026-02367-0Klimmt, Cardoso Gonçalves et al. developed a reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and...