Sustained antidepressant-like effects of psychedelics through 5-HT2AR–β-arrestin signaling

by Clinical Neuropsychologist Online | Friday, October 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 October 2026; doi:10.1038/s41593-026-02497-5This study shows that the sustained antidepressant-like effect of psychedelics is driven by 5-HT2A receptor–β-arrestin signaling. Repeated low-dose LSD preserves this effect in mice...

Behavioral genomics identifies Creld1 as a cross-modal regulator of somatosensation

by Clinical Neuropsychologist Online | Thursday, October 22, 2026 | Neuroscience

Nature Neuroscience, Published online: 22 October 2026; doi:10.1038/s41593-026-02484-wJiang et al. developed a robust postnatal knockout platform for somatosensory genomics and behavioral screening, identifying Creld1 as a cross-modal regulator of somatosensation...

Network geometry shapes the transformation of task representations across the human cortex

by Clinical Neuropsychologist Online | Thursday, October 22, 2026 | Neuroscience

Nature Neuroscience, Published online: 22 October 2026; doi:10.1038/s41593-026-02486-8The dimensionality of intrinsic brain connectivity systematically shapes how task representations compress and expand across the cortex, and activity flow modeling shows the active...

SIK3 controls synaptic localization of NMDA receptors by phosphorylating GluN1

by Clinical Neuropsychologist Online | Wednesday, October 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 October 2026; doi:10.1038/s41593-026-02469-9SIK3 kinase controls synaptic NMDA receptor recruitment by phosphorylating GluN1 at a single site. Loss or inhibition of SIK3 markedly reduces synaptic NMDARs, while a...

A corticohypothalamic circuit that mediates maternal awakening to pup cries

by Clinical Neuropsychologist Online | Wednesday, October 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 October 2026; doi:10.1038/s41593-026-02458-yTang, Wu et al. identify a brain circuit that enables mother mice to wake selectively to pup cries. Motherhood strengthens this pathway through increased dopamine receptor D1...

Early lineage divergence segregates sensory and motor-associative identities in the thalamus

by Clinical Neuropsychologist Online | Tuesday, October 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 October 2026; doi:10.1038/s41593-026-02485-9Sensory and motor-associative identities in the thalamus arise from two early-diverging lineages, with sensory neurons progressing through shared intermediate states, revealing how...