A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02090-2Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations. The...

Estrogen modulates reward prediction errors and reinforcement learning

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02104-zDopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake...

APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02094-yUsing a mouse model enabling an inducible ‘switch’, Golden et al. show that an astrocyte-specific replacement of the Alzheimer’s risk gene APOE4 with protective APOE2 alters...

High estrogen states enhance reinforcement learning

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02105-yWe have all heard the cliché; hormones make us unreliable and unpredictable. However, in this issue of Nature Neuroscience, Golden et al. show that higher states of endogenous...

Flipping APOE to reverse Alzheimer’s disease traits

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02108-9In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo ‘switching’ from the Alzheimer’s risk gene APOE4 to the protective gene APOE2. This...

Unanswered Questions About the Human Brain

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Even after decades of groundbreaking research, the human brain ;remains only ;partially understood. Fundamental questions persist about consciousness, cognition, memory, and neural plasticity. As neuroscience integrates with fields like AI and genetics, we continue to...