Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility

by Clinical Neuropsychologist Online | Tuesday, June 2, 2026 | Neuroscience

Nature Neuroscience, Published online: 02 June 2026; doi:10.1038/s41593-026-02321-0This study shows that androgens signal to specific enteric neurons to stimulate gut motility. Bacterial metabolism of host-derived steroids generates the ligands, revealing a dynamic...

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02301-4In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism...

Why pain biomarkers cannot replace the patient experience

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02324-xUsing neuroimaging to understand the mechanisms of pain is an important task. But we must understand that the gold standard of measuring pain will always be the self-report. If you do...

Towards a holistic understanding of pain in the biomarker age

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02323-yPain biomarkers cannot prove or disprove another person’s pain, but they need not be rejected as futile or reductionist. When developed within a bio-psycho-social framework and guided...

Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner

by Clinical Neuropsychologist Online | Friday, May 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02297-xA cellular explanation for how tau aggregates into fibrils in Alzheimer’s disease has been elusive. This paper identifies the failure of ‘neuroproteasomes’ as sufficient to convert tau...

An unexpected molecular explanation for how tau aggregation begins in Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, May 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02298-wDisruption of a neuronal-specific protein degradation system, the plasma membrane-bound neuroproteasome, triggers the conversion of endogenous tau into aggregates that mirror those seen...