A competitive disinhibitory network for robust optic flow processing in Drosophila

by Clinical Neuropsychologist | Thursday, May 1, 2025 | Neuroscience

Nature Neuroscience, Published online: 01 May 2025; doi:10.1038/s41593-025-01948-9Navigation relies on detecting left versus right body asymmetries for gaze and course stability. A central three-layer optic flow-sensitive network with competitive lateral disinhibition...

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia

by Clinical Neuropsychologist | Wednesday, April 30, 2025 | Neuroscience

Nature Neuroscience, Published online: 30 April 2025; doi:10.1038/s41593-025-01936-zIn this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic...

Moving Beyond Traditional Pathways in Cognitive Neuroscience

by Clinical Neuropsychologist | Tuesday, April 22, 2025 | Neuroscience

CNS 2025 guest post by Lauren Homann (CNSTA president) As cognitive neuroscience trainees look toward the future, many are considering options beyond traditional academic pathways. With growing uncertainty around research funding, increasing academic precarity, and a...

Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila

by Clinical Neuropsychologist | Monday, April 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 April 2025; doi:10.1038/s41593-025-01942-1Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells...

Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes

by Clinical Neuropsychologist | Monday, April 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 April 2025; doi:10.1038/s41593-025-01943-0Sznajder et al. identified a molecular link between autism and myotonic dystrophy, showing that a tandem repeat mutation in a single gene can disrupt splicing of multiple...

Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex

by Clinical Neuropsychologist | Monday, April 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 April 2025; doi:10.1038/s41593-025-01933-2Nano et al. introduce a pipeline to generate meta-atlases of the human brain from existing single-cell datasets and extract gene modules linked to cell fate specification. Perturbing...