Neuropixels go ultra

by Clinical Neuropsychologist | Wednesday, January 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 January 2026; doi:10.1038/s41593-025-02193-wNeuropixels go ultra If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright:...

Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion

by Clinical Neuropsychologist | Tuesday, January 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 January 2026; doi:10.1038/s41593-025-02162-3Kukreja, Jeon et al. leverage spatial transcriptomics to map immune gene expression in the developing mouse brain, identifying key sex-specific changes in the context of maternal...

CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment

by Clinical Neuropsychologist | Monday, January 5, 2026 | Neuroscience

Nature Neuroscience, Published online: 05 January 2026; doi:10.1038/s41593-025-02165-0We conducted a CRISPR screen to identify genes essential for neural differentiation. By integrating these findings with mouse neuroanatomy, we demonstrated its utility in discovering...

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration

by Clinical Neuropsychologist | Friday, January 2, 2026 | Neuroscience

Nature Neuroscience, Published online: 02 January 2026; doi:10.1038/s41593-025-02161-4Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism...

Position-independent emergence of neocortical neuron molecular identity, connectivity and function

by Clinical Neuropsychologist | Wednesday, December 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 December 2025; doi:10.1038/s41593-025-02142-7Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental...

Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus

by Clinical Neuropsychologist | Tuesday, December 30, 2025 | Neuroscience

Nature Neuroscience, Published online: 30 December 2025; doi:10.1038/s41593-025-02148-1Distinct endocannabinoids signal to either astrocytes or neurons, evoking contrasting regulation of synaptic function. This works reveals the high degree of complexity of neuronal...