Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, July 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 July 2026; doi:10.1038/s41593-026-02390-1Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they...

Experience reorganizes content-specific memory traces in macaques

by Clinical Neuropsychologist Online | Wednesday, July 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 July 2026; doi:10.1038/s41593-026-02357-2In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep...

Replay of procedural memory is independent of the hippocampus

by Clinical Neuropsychologist Online | Thursday, July 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02362-5Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior...

Focal astrocyte loss reveals nuclear translocation during lesion repopulation

by Clinical Neuropsychologist Online | Thursday, July 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02354-5Herwerth et al. demonstrate that, after focal astrocyte loss in the adult brain, perilesional astrocytes undergo extensive remodeling, proliferation and nuclear translocation to...

Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

by Clinical Neuropsychologist Online | Wednesday, July 22, 2026 | Neuroscience

Nature Neuroscience, Published online: 22 July 2026; doi:10.1038/s41593-026-02358-1The authors show that cerebral venous blood flow and meningeal lymphatics co-regulate intracranial pressure and brain clearance in mice and humans. This finding supports idiopathic...

Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal–prefrontal synchrony

by Clinical Neuropsychologist Online | Monday, July 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 July 2026; doi:10.1038/s41593-026-02369-yYu, Zhang et al. show that repeated exposure to the psychedelic drug 25C-NBOMe in adolescent rats, but not in adult rats, reduces willingness to engaged in food resource competition in...