Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations

by Clinical Neuropsychologist Online | Friday, August 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 August 2026; doi:10.1038/s41593-026-02391-0A multimodal cell-type atlas of the mouse insular cortex reveals specialized pyramidal types and circuits in distinct insular subregions, as well as intra-insular functional...

Striatal endocannabinoids drive one-shot learning

by Clinical Neuropsychologist Online | Friday, August 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 August 2026; doi:10.1038/s41593-026-02392-zEndocannabinoid-dependent corticostriatal plasticity underlies avoidance learning in mice after a single experience. Disrupting this process impairs learning, revealing a nonclassical...

A suite of engineered mice for interrogating psychedelic drug actions

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02375-0Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across...

Neuroligin-3–CSPG4 interaction maintains oligodendrocyte precursor cell progenitor state and promotes glioma proliferation through mechanotransduction

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02397-8This study finds that shed NLGN3 interacts with the glycosylated surface protein CSPG4 on both normal and malignant glial cells, activating mechanotransduction pathways that drive...

Comparative insights into insula structure and function

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Neuroscience

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02380-3Charbonneau et al. compare how the insula is structured and functions in humans, monkeys and rodents, revealing similarities and differences across species that are likely to impact...

Norepinephrine and dopamine sensor crosstalk depends on local innervation density

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Neuroscience

Nature Neuroscience, Published online: 05 August 2026; doi:10.1038/s41593-026-02379-wThis study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and...