Layer-specific changes in sensory cortex across the lifespan in mice and humans

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02013-1The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep layer...

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02039-5By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing mechanism that...

A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02040-yThe mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive...

Differential kinematic coding in sensorimotor striatum across behavioral domains reflects different contributions to movement

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02026-wHardcastle and Marshall et al. show that striatal function is domain specific, required for task-related but not spontaneously expressed movements. This functional distinction is...

Serotonergic modulation of the BNST–CeA pathway reveals sex differences in fear learning

by Clinical Neuropsychologist | Wednesday, August 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 August 2025; doi:10.1038/s41593-025-02025-xRavenelle et al. show that systematically increasing serotonin has sex-specific effects on fear learning in mice. In females only, increasing serotonin in the BNST enhances fear...

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

by Clinical Neuropsychologist | Wednesday, August 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 August 2025; doi:10.1038/s41593-025-02010-4Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed...