A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02040-yThe mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive...

Differential kinematic coding in sensorimotor striatum across behavioral domains reflects different contributions to movement

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02026-wHardcastle and Marshall et al. show that striatal function is domain specific, required for task-related but not spontaneously expressed movements. This functional distinction is...

Serotonergic modulation of the BNST–CeA pathway reveals sex differences in fear learning

by Clinical Neuropsychologist | Wednesday, August 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 August 2025; doi:10.1038/s41593-025-02025-xRavenelle et al. show that systematically increasing serotonin has sex-specific effects on fear learning in mice. In females only, increasing serotonin in the BNST enhances fear...

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

by Clinical Neuropsychologist | Wednesday, August 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 August 2025; doi:10.1038/s41593-025-02010-4Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed...

Alzheimer’s disease transcriptional landscape in ex vivo human microglia

by Clinical Neuropsychologist | Monday, August 4, 2025 | Neuroscience

Nature Neuroscience, Published online: 04 August 2025; doi:10.1038/s41593-025-02020-2Here the authors provide a comprehensive transcriptomic dataset of human primary microglia for Alzheimer’s disease and healthy aging. They identify dysregulation of immune-related...

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

by Clinical Neuropsychologist | Monday, August 4, 2025 | Neuroscience

Nature Neuroscience, Published online: 04 August 2025; doi:10.1038/s41593-025-02021-1Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT2AR activation without immediately...