Neuropeptide Y co-opts neuronal ensembles for memory lability and stability

by Clinical Neuropsychologist Online | Tuesday, March 31, 2026 | Neuroscience

Nature Neuroscience, Published online: 31 March 2026; doi:10.1038/s41593-026-02235-xThis study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories...

Null models for lesion network mapping

by Clinical Neuropsychologist Online | Monday, March 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 March 2026; doi:10.1038/s41593-026-02259-3Van den Heuvel et al. show that lesion-network mapping (LNM)-derived circuits converge across disorders and argue that this convergence reflects a fundamental methodological limitation...

Neuroimmune interferon signals sustain arthritis pain

by Clinical Neuropsychologist Online | Monday, March 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 March 2026; doi:10.1038/s41593-026-02251-xPain in rheumatoid arthritis often persists independently of joint inflammation. In this issue, Su et al. demonstrate that sustained non-canonical type 1 interferon signaling within...

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

by Clinical Neuropsychologist Online | Monday, March 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 March 2026; doi:10.1038/s41593-026-02226-yALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and...

The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations

by Clinical Neuropsychologist Online | Friday, March 27, 2026 | Neuroscience

Nature Neuroscience, Published online: 27 March 2026; doi:10.1038/s41593-026-02240-0This study reveals how the dentate gyrus gradually learns to integrate olfactory and spatial signals from the entorhinal cortex, transforming them into sparse and highly specific...

The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions

by Clinical Neuropsychologist Online | Thursday, March 26, 2026 | Neuroscience

Nature Neuroscience, Published online: 26 March 2026; doi:10.1038/s41593-026-02239-7A new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in...