Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner

by Clinical Neuropsychologist Online | Friday, May 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02297-xA cellular explanation for how tau aggregates into fibrils in Alzheimer’s disease has been elusive. This paper identifies the failure of ‘neuroproteasomes’ as sufficient to convert tau...

An unexpected molecular explanation for how tau aggregation begins in Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, May 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02298-wDisruption of a neuronal-specific protein degradation system, the plasma membrane-bound neuroproteasome, triggers the conversion of endogenous tau into aggregates that mirror those seen...

The multiple scales of astrocytic functional units

by Clinical Neuropsychologist Online | Wednesday, May 27, 2026 | Neuroscience

Nature Neuroscience, Published online: 27 May 2026; doi:10.1038/s41593-026-02308-xAstrocytes modulate complex brain functions. These ubiquitous glial cells constitute a multilayered system of functional units that operate across multiple spatial scales, thereby...

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice

by Clinical Neuropsychologist Online | Tuesday, May 26, 2026 | Neuroscience

Nature Neuroscience, Published online: 26 May 2026; doi:10.1038/s41593-026-02317-wIn PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to astrocytes. This...

Fixation duration on natural scenes is explained by memory encoding not processing demand

by Clinical Neuropsychologist Online | Monday, May 25, 2026 | Neuroscience

Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02285-1By combining magnetoencephalography and eye tracking, this study sheds light on why people fixate on some parts of natural scenes longer than others. Rather than visual complexity,...

Low-dimensional population dynamics in the brainstem gate REM sleep

by Clinical Neuropsychologist Online | Monday, May 25, 2026 | Neuroscience

Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02314-zLozano et al. show that REM sleep is gated by low-dimensional brainstem network dynamics, in which opposing neuron populations across the midbrain and pons determine when transitions...