Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks

by Clinical Neuropsychologist | Friday, December 19, 2025 | Neuroscience

Nature Neuroscience, Published online: 19 December 2025; doi:10.1038/s41593-025-02139-2This study shows that animals can adapt behaviorally to warm environments by speeding up their internal clocks. Suprathreshold temperatures activate the Lim1 pathway in the fly...

Freezing forgetting in C. elegans to extend memory retention

by Clinical Neuropsychologist | Friday, December 19, 2025 | Neuroscience

Nature Neuroscience, Published online: 19 December 2025; doi:10.1038/s41593-025-02145-4We explored how external conditions shape cognitive function. Classical olfactory learning assays revealed that Caenorhabditis elegans kept on ice or treated with lithium exhibited...

Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans

by Clinical Neuropsychologist | Thursday, December 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 December 2025; doi:10.1038/s41593-025-02143-6In this study, we identify an actively regulated process that governs the rate of forgetting in Caenorhabditis elegans, modulated by both temperature and the mood-stabilizing drug...

CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s disease

by Clinical Neuropsychologist | Thursday, December 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 December 2025; doi:10.1038/s41593-025-02154-3This study reveals how distal DNA ‘switches’ control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer–gene links, highlight...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons

by Clinical Neuropsychologist | Wednesday, December 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 December 2025; doi:10.1038/s41593-025-02157-0The authors found that the Alzheimer’s disease-associated protein tau, widely considered pathogenic when hyperphosphorylated, has a natural function as part of the innate immune...

Taking Action Seriously in the Brain: Revealing the Role of Cognition in Motor Skills

by Clinical Neuropsychologist | Tuesday, December 16, 2025 | Neuroscience

CNS 2026 Q&A with Samuel McDougle As a member of a Connecticut-based band, Samuel McDougle has many opportunities to display a range of motor skills on a regular basis, whether playing bluegrass fiddle, mandolin, or guitar. From his love of music has sprung a...