Taking Action Seriously in the Brain: Revealing the Role of Cognition in Motor Skills

by Clinical Neuropsychologist | Tuesday, December 16, 2025 | Neuroscience

CNS 2026 Q&A with Samuel McDougle As a member of a Connecticut-based band, Samuel McDougle has many opportunities to display a range of motor skills on a regular basis, whether playing bluegrass fiddle, mandolin, or guitar. From his love of music has sprung a...

BOLD signal changes can oppose oxygen metabolism across the human cortex

by Clinical Neuropsychologist | Tuesday, December 16, 2025 | Neuroscience

Nature Neuroscience, Published online: 16 December 2025; doi:10.1038/s41593-025-02132-9Using quantitative brain imaging, the authors show opposite fMRI BOLD signal to metabolic activity due to variable oxygen extraction across the human cortex. This questions the...

The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling

by Clinical Neuropsychologist | Monday, December 15, 2025 | Neuroscience

Nature Neuroscience, Published online: 15 December 2025; doi:10.1038/s41593-025-02136-5We show that FOXF2 maintains cerebrovascular function through Tie2 signaling, and that pharmacological activation of Tie2 with AKB-9778 rescues deficits in cerebral small vessel...

A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions

by Clinical Neuropsychologist | Monday, December 15, 2025 | Neuroscience

Nature Neuroscience, Published online: 15 December 2025; doi:10.1038/s41593-025-02123-wGonzalez-Gallego et al. developed a fully iPS-cell-based human three-dimensional blood–brain barrier (BBB) model and used it to study roles of the stroke risk gene FOXF2 in BBB...

Bright light exposure suppresses feeding and weight gain via a visual circuit linked to the lateral hypothalamus

by Clinical Neuropsychologist | Friday, December 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 December 2025; doi:10.1038/s41593-025-02156-1Bright light reduces feeding and weight gain in mice by activating a specific retina-to-brain pathway that signals through the visual thalamus to inhibit appetite-regulating neurons...

Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex?

by Clinical Neuropsychologist | Friday, December 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 December 2025; doi:10.1038/s41593-025-02167-yIs there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex? If you do not see content above, kindly GO TO SOURCE. Not all publishers encode...