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Data sharing as the foundation of discovery: ADNI and breakthroughs in Alzheimer’s disease

by Clinical Neuropsychologist | Tuesday, July 30, 2024 | Dementia

Abstract The COVID pandemic has shown that when the research community comes together, we can conquer the most complex biomedical challenges. Collaboration and teamwork among federal agencies, private organizations, and researchers have been crucial in the development...

A functional aged human iPSC‐cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics

by Clinical Neuropsychologist | Tuesday, July 30, 2024 | Dementia

Abstract INTRODUCTION The degeneration of cortical layers is associated with cognitive decline in Alzheimer’s disease (AD). Current therapies for AD are not disease-modifying, and, despite substantial efforts, research and development for AD has faced formidable...

A genetic and proteomic comparison of key AD biomarkers across tissues

by Clinical Neuropsychologist | Tuesday, July 30, 2024 | Dementia

Abstract INTRODUCTION Plasma has been proposed as an alternative to cerebrospinal fluid (CSF) for measuring Alzheimer’s disease (AD) biomarkers, but no studies have analyzed in detail which biofluid is more informative for genetics studies of AD. METHOD Eleven...

Foreclosure, memory decline, and dementia probability: A longitudinal cohort study

by Clinical Neuropsychologist | Monday, July 29, 2024 | Dementia

Abstract INTRODUCTION Housing insecurity is rising among older adults; health researchers know little about how this may impact their cognitive health. We investigated links between foreclosure and older adults’ memory and probability of dementia. METHODS Using the...

Scenarios for the long‐term efficacy of amyloid‐targeting therapies in the context of the natural history of Alzheimer’s disease

by Clinical Neuropsychologist | Monday, July 29, 2024 | Dementia

Abstract INTRODUCTION Recent clinical trials of amyloid beta (Aβ)-targeting therapies in Alzheimer’s disease (AD) have demonstrated a clinical benefit over 18 months, but their long-term impact on disease trajectory is not yet understood. We propose a framework...
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