by Clinical Neuropsychologist | Monday, June 17, 2024 | Dementia
Abstract Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid protein in the walls of cerebral blood vessels. This deposition of amyloid causes damage to the cerebral vasculature, resulting in blood-brain barrier disruption, cerebral...
by Clinical Neuropsychologist | Saturday, June 15, 2024 | Dementia
Abstract INTRODUCTION TAR DNA-binding protein 43 (TDP-43) is a highly prevalent proteinopathy that is involved in neurodegenerative processes, including axonal damage. To date, no ante mortem biomarkers exist for TDP-43, and few studies have directly assessed its...
by Clinical Neuropsychologist | Saturday, June 15, 2024 | Dementia
Abstract INTRODUCTION The contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated. METHODS We analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities...
by Clinical Neuropsychologist | Saturday, June 15, 2024 | Dementia
Abstract BACKGROUND The mechanisms linking mild behavioral impairment (MBI) and Alzheimer’s disease (AD) have been insufficiently explored, with conflicting results regarding tau protein and few data on other metabolic markers. We aimed to evaluate the...
by Clinical Neuropsychologist | Saturday, June 15, 2024 | Dementia
Abstract INTRODUCTION The entorhinal cortex (EC) and perirhinal cortex (PC) are vulnerable to Alzheimer’s disease. A triggering factor may be the interaction of vascular dysfunction and tau pathology. METHODS We imaged post mortem human tissue at 100 μm3 with 7...
