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Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model

by Clinical Neuropsychologist Online | Tuesday, July 23, 2024 | Dementia

Abstract INTRODUCTION Tau-positron emission tomography (PET) outcome data of patients with Alzheimer’s disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation,...

Predicting continuous amyloid PET values with CSF tau phosphorylation occupancies

by Clinical Neuropsychologist Online | Tuesday, July 23, 2024 | Dementia

Abstract INTRODUCTION Cerebrospinal fluid (CSF) tau phosphorylation at multiple sites is associated with cortical amyloid and other pathologic changes in Alzheimer’s disease. These relationships can be non-linear. We used an artificial neural network to assess...

Reasons for undergoing amyloid imaging among diverse enrollees in the A4 study

by Clinical Neuropsychologist Online | Tuesday, July 23, 2024 | Dementia

Abstract INTRODUCTION Understanding attitudes toward participation among diverse preclinical Alzheimer’s disease (AD) trial participants could yield insights to instruct future recruitment. METHODS Using data from the Anti-Amyloid Treatment in Asymptomatic AD...

Enabling work for people with dementia – Recommendations for interventions: A mixed-methods review

by Clinical Neuropsychologist Online | Tuesday, July 23, 2024 | Dementia

Dementia, Volume 23, Issue 8, Page 1382-1415, November 2024. Worldwide, 50 million people are living with dementia. As more individuals develop dementia while still working, dementia will increasingly become a workplace issue and a societal concern. Interventions...

Associations of cerebral amyloid beta and tau with cognition from midlife

by Clinical Neuropsychologist Online | Tuesday, July 23, 2024 | Dementia

Abstract INTRODUCTION Understanding early neuropathological changes and their associations with cognition may aid dementia prevention. This study investigated associations of cerebral amyloid and tau positron emission tomography (PET) retention with cognition in a...
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