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Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi‐site validation in the MarkVCID Consortium

by Clinical Neuropsychologist | Tuesday, July 2, 2024 | Dementia

Abstract INTRODUCTION Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance...

Reproductive hormones in relation to white matter hyperintensity volumes among midlife women

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION Although reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume (WMHV), a key indicator of cerebral small vessel disease. Even fewer...

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in...

Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION The study aimed to investigate the associations of changes in social isolation, loneliness, or both, with cognitive function. METHODS Data were from 7299 older adults in the Chinese Longitudinal Healthy Longevity Survey. We defined four change...

The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample. METHODS For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the...
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