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Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION The study aimed to investigate the associations of changes in social isolation, loneliness, or both, with cognitive function. METHODS Data were from 7299 older adults in the Chinese Longitudinal Healthy Longevity Survey. We defined four change...

The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample. METHODS For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the...

Effect of early menopause on cognition and brain morphology in an Urban Indian Cohort

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND Evidence for the effect of early menopause on cognition among older women is not consistent and is scant among the Indian population. METHODS We aimed to examine the effect of early menopause (≤45 years) on cognitive performance and brain...

Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION Vervets are non-human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics. METHODS Amyloid...

Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer’s disease

by Clinical Neuropsychologist | Friday, June 28, 2024 | Dementia

Abstract BACKGROUND This study investigated the potential of phosphorylated plasma Tau217 ratio (pTau217R) and plasma amyloid beta (Aβ) 42/Aβ40 in predicting brain amyloid levels measured by positron emission tomography (PET) Centiloid (CL) for Alzheimer’s...
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