by Clinical Neuropsychologist | Saturday, June 22, 2024 | Dementia
Abstract INTRODUCTION We examined whether the aging suppressor KLOTHO gene’s functionally advantageous KL-VS variant (KL-VS heterozygosity [KL-VSHET]) confers resilience against deleterious effects of aging indexed by cerebrospinal fluid (CSF) biomarkers of...
by Clinical Neuropsychologist | Saturday, June 22, 2024 | Dementia
Abstract INTRODUCTION Bumetanide, a loop diuretic, was identified as a candidate drug for repurposing for Alzheimer’s disease (AD) based on its effects on transcriptomic apolipoprotein E signatures. Cross-sectional analyses of electronic health records suggest...
by Clinical Neuropsychologist | Friday, June 21, 2024 | Dementia
Abstract INTRODUCTION Estimating treatment effects as time savings in disease progression may be more easily interpretable than assessing the absolute difference or a percentage reduction. In this study, we investigate the statistical considerations of the existing...
by Clinical Neuropsychologist | Friday, June 21, 2024 | Dementia
Dementia, Volume 23, Issue 7, Page 1103-1125, October 2024. IntroductionPeople living with young-onset dementia and their care-partners are at risk of a range of adverse mental health outcomes and social isolation. There are few interventions aimed at supporting...
by Clinical Neuropsychologist | Friday, June 21, 2024 | Dementia
Abstract INTRODUCTION The understanding of the pathological events in Alzheimer’s disease (AD) has advanced dramatically, but the successful translation from rodent models into efficient human therapies is still problematic. METHODS To examine how tau pathology...
