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Cognitive integrity in Non‐Demented Individuals with Alzheimer’s Neuropathology is associated with preservation and remodeling of dendritic spines

by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia

Abstract INTRODUCTION Individuals referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN) exhibit cognitive resilience despite presenting Alzheimer’s disease (AD) histopathological signs. Investigating the mechanisms behind this resilience may...

Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance

by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia

Abstract INTRODUCTION Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication...

Crosstalk between bone and brain in Alzheimer’s disease: Mechanisms, applications, and perspectives

by Clinical Neuropsychologist | Monday, June 3, 2024 | Dementia

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease that involves multiple systems in the body. Numerous recent studies have revealed bidirectional crosstalk between the brain and bone, but the interaction between bone and brain in AD remains...

The presenilin 1 mutation P436S causes familial Alzheimer’s disease with elevated Aβ43 and atypical clinical manifestations

by Clinical Neuropsychologist | Sunday, June 2, 2024 | Dementia

Abstract INTRODUCTION Familial Alzheimer’s disease (fAD) is heterogeneous in terms of age at onset and clinical presentation. A greater understanding of the pathogenicity of fAD variants and how these contribute to heterogeneity will enhance our understanding of...

Time perception among people living with and without dementia: A scoping review

by Clinical Neuropsychologist | Saturday, June 1, 2024 | Dementia

Dementia, Volume 23, Issue 7, Page 1183-1211, October 2024. Dementia often manifests with profound alterations in perception, but it is unclear if and to what extent time perception is altered among people living with dementia compared to those experiencing normal...
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