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The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study

by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample. METHODS For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the...

Effect of early menopause on cognition and brain morphology in an Urban Indian Cohort

by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND Evidence for the effect of early menopause on cognition among older women is not consistent and is scant among the Indian population. METHODS We aimed to examine the effect of early menopause (≤45 years) on cognitive performance and brain...

Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION Vervets are non-human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics. METHODS Amyloid...

Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, June 28, 2024 | Dementia

Abstract BACKGROUND This study investigated the potential of phosphorylated plasma Tau217 ratio (pTau217R) and plasma amyloid beta (Aβ) 42/Aβ40 in predicting brain amyloid levels measured by positron emission tomography (PET) Centiloid (CL) for Alzheimer’s...

The link between gut microbiome and Alzheimer’s disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, June 28, 2024 | Dementia

Abstract Over the past decades, accumulating evidence suggests that the gut microbiome exerts a key role in Alzheimer’s disease (AD). The Alzheimer’s Association Workgroup is updating the diagnostic criteria for AD, which changed the profiles and...
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