by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia
Abstract INTRODUCTION Despite a two-fold risk, individuals of African ancestry have been underrepresented in Alzheimer’s disease (AD) genomics efforts. METHODS Genome-wide association studies (GWAS) of 2,903 AD cases and 6,265 controls of African ancestry....
by Clinical Neuropsychologist Online | Tuesday, July 2, 2024 | Dementia
Abstract INTRODUCTION Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance...
by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia
Abstract INTRODUCTION Although reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume (WMHV), a key indicator of cerebral small vessel disease. Even fewer...
by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia
Abstract INTRODUCTION We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in...
by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia
Abstract INTRODUCTION The study aimed to investigate the associations of changes in social isolation, loneliness, or both, with cognitive function. METHODS Data were from 7299 older adults in the Chinese Longitudinal Healthy Longevity Survey. We defined four change...
