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HbA1c variability associated with dementia risk in people with type 2 diabetes

by Clinical Neuropsychologist Online | Thursday, July 4, 2024 | Dementia

Abstract INTRODUCTION Although poor glycemic control is associated with dementia, it is unknown if variability in glycemic control, even in those with optimal glycosylated hemoglobin A1c (HbA1c) levels, increases dementia risk. METHODS Among 171,964 people with type 2...

Nanoscale flow cytometry‐based quantification of blood‐based extracellular vesicle biomarkers distinguishes MCI and Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION Accurate testing for Alzheimer’s disease (AD) represents a crucial step for therapeutic advancement. Currently, tests are expensive and require invasive sampling or radiation exposure. METHODS We developed a nanoscale flow cytometry...

The role of the Alzheimer’s Disease Neuroimaging Initiative in establishing the Dominantly Inherited Alzheimer Network

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract The Dominantly Inherited Alzheimer Network (DIAN) initially was funded by the National Institute on Aging (NIA) in 2008 and thus was able to adopt and incorporate the protocols developed by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) that had...

Time‐encoded ASL reveals lower cerebral blood flow in the early AD continuum

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer’s disease (AD) patients. We checked the sensitivity of time-encoded arterial spin labeling (te-ASL) in measuring CBF alterations in individuals with positive AD...

Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI is critical for comprehending disease progression and enabling preventative intervention. METHODS Patients with MCI...
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