Assessment of brain‐derived extracellular vesicle enrichment for blood biomarker analysis in age‐related neurodegenerative diseases: An international overview

Abstract INTRODUCTION Brain-derived extracellular vesicles (BEVs) in blood allows for minimally-invasive investigations of central nervous system (CNS) -specific markers of age-related neurodegenerative diseases (NDDs). Polymer-based EV- and immunoprecipitation...

The risk of Alzheimer’s disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis

Abstract INTRODUCTION The cognitive impairment patterns and the association with Alzheimer’s disease (AD) in mental disorders remain poorly understood. METHODS We analyzed data from 486,297 UK Biobank participants, categorizing them by mental disorder history to...

Unraveling the multiple chronic conditions patterns among people with Alzheimer’s disease and related dementia: A machine learning approach to incorporate synergistic interactions

Abstract INTRODUCTION Most people with Alzheimer’s disease and related dementia (ADRD) also suffer from two or more chronic conditions, known as multiple chronic conditions (MCC). While many studies have investigated the MCC patterns, few studies have considered...