by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia
Abstract INTRODUCTION We investigate pathological correlates of plasma phosphorylated tau 181 (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) across a clinically diverse spectrum of neurodegenerative disease, including normal...
by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia
Abstract BACKGROUND Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS We included 195 adults...
by Clinical Neuropsychologist Online | Thursday, April 18, 2024 | Dementia
Abstract BACKGROUND Alzheimer’s disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associated with such resilience against AD. METHODS...
by Clinical Neuropsychologist Online | Thursday, April 18, 2024 | Dementia
Abstract INTRODUCTION Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of...
by Clinical Neuropsychologist Online | Thursday, April 18, 2024 | Dementia
Promoting cardiovascular health (CVH) by Life’s Simple 7 is associated with better cognitive function. In 2022, the American Heart Association (AHA) prompted Life’s Essential 8 (LE8) to strengthen CVH assessment. This study investigated the association between the new...
