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Dementias Platform UK: Bringing genetics into life

by Clinical Neuropsychologist Online | Wednesday, March 20, 2024 | Dementia

Abstract INTRODUCTION The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is...

Age of Alzheimer’s disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium

by Clinical Neuropsychologist Online | Wednesday, March 20, 2024 | Dementia

Abstract INTRODUCTION People with Down syndrome (DS) have high risk of developing Alzheimer’s disease (AD). This study examined mean ages of AD diagnosis and associations with co-occurring conditions among adults with DS from five European countries. METHODS...

Racial, ethnic, and rural disparities in distance to physicians among decedents with Alzheimer’s disease and related dementias in Washington State

by Clinical Neuropsychologist Online | Wednesday, March 20, 2024 | Dementia

Abstract INTRODUCTION Distance to physicians may explain some of the disparities in Alzheimer’s disease and related dementia (AD/ADRD) outcomes. METHODS We generated round trip distance between residences of decedents with AD/ADRD and the nearest neurologist and...

Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, March 19, 2024 | Dementia

Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer’s disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS...

Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling

by Clinical Neuropsychologist Online | Tuesday, March 19, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective...
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