by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia
Abstract Tau pathology is more closely associated with cognitive deterioration than amyloid burden in symptomatic Alzheimer’s disease (AD), yet tau-targeted trials have often interpreted decreases in soluble phosphorylated tau (p-tau) as evidence of therapeutic...
by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia
Abstract The therapeutic landscape of Alzheimer’s disease (AD) is rapidly evolving with the clinical adoption of anti-amyloid monoclonal antibodies (mAbs) despite an incomplete understanding of disease mechanisms, progression, and heterogeneity. Designing both...
by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia
Abstract INTRODUCTION Genetic factors contribute to variability in age-related cognitive decline, yet the molecular mechanisms underlying cognitive resilience remain poorly understood. METHODS We performed single-nucleus RNA sequencing on hippocampal tissue from 107...
by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia
Abstract INTRODUCTION Limbic-predominant age-related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE-NC) is common in older adults, yet definitive diagnosis is only possible at autopsy. METHODS This work developed a fully...
by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia
Abstract INTRODUCTION We studied dementia incidence and risk factors in Indigenous Tsimane and Moseten Amerindian populations in Amazonian Bolivia with largely subsistence lifestyles. METHODS A median of 4.7 years after baseline dementia assessment, 730 participants...
