by Clinical Neuropsychologist Online | Wednesday, March 13, 2024 | Dementia
Abstract INTRODUCTION White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-β1-42 (Aβ42)-positive...
by Clinical Neuropsychologist Online | Wednesday, March 13, 2024 | Dementia
Abstract INTRODUCTION Trials of effectiveness of treatment options for depression in dementia are an important priority. METHODS Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by...
by Clinical Neuropsychologist Online | Wednesday, March 13, 2024 | Dementia
Abstract INTRODUCTION This review examines the concept of cognitive reserve (CR) in relation to brain aging, particularly in the context of dementia and its early stages. CR refers to an individual’s ability to maintain or regain cognitive function despite brain...
by Clinical Neuropsychologist Online | Tuesday, March 12, 2024 | Dementia
Abstract INTRODUCTION Apolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism...
by Clinical Neuropsychologist Online | Tuesday, March 12, 2024 | Dementia
Abstract BACKGROUND Impairment of the ubiquitin-proteasome system (UPS) has been implicated in abnormal protein accumulation in Alzheimer’s disease. It remains unclear if genetic variation affects the intrinsic properties of neurons that render some individuals...
