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APOE ε4 carrier status modifies plasma p‐tau181 concentrations in cognitively healthy super‐seniors

by Clinical Neuropsychologist Online | Thursday, May 16, 2024 | Dementia

Abstract INTRODUCTION This study investigates the effect of apolipoprotein E (APOE) genotype on neurology plasma biomarkers in cognitively healthy Super-Seniors. METHODS Three hundred seventy plasma specimens from Super-Senior participants ≥ 85 years old, who have...

Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer’s disease independent of amyloid and tau pathology

by Clinical Neuropsychologist Online | Monday, May 13, 2024 | Dementia

Abstract INTRODUCTION MODEL-AD (Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease) is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to capture the trajectory and progression of...

Blood biomarkers of Alzheimer’s disease in the community: Variation by chronic diseases and inflammatory status

by Clinical Neuropsychologist Online | Thursday, May 9, 2024 | Dementia

Abstract INTRODUCTION We explored the variations of blood biomarkers of Alzheimer’s disease (AD) by chronic diseases and systemic inflammation. METHODS We explored the association of AD blood biomarkers with chronic diseases and systemic inflammation...

Antidepressant exposure and long‐term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder

by Clinical Neuropsychologist Online | Wednesday, May 8, 2024 | Dementia

Abstract INTRODUCTION The use of antidepressants in major depressive disorder (MDD) has been reported to influence long-term risk of Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD), but studies are conflicting. METHODS We used inverse probability...

Long‐term exposure to air pollution and road traffic noise and incidence of dementia in the Danish Nurse Cohort

by Clinical Neuropsychologist Online | Wednesday, May 8, 2024 | Dementia

Abstract INTRODUCTION We examined the association of long-term exposure to air pollution and road traffic noise with dementia incidence in the Danish Nurse Cohort. METHODS Female nurses were followed for dementia incidence (hospital contact or medication prescription)...
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