by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) is the leading cause of dementia, affecting around 50 million individuals worldwide. Brain-derived extracellular vesicles (EVs) can cross the blood–brain barrier carrying neuron-specific molecules, such as microRNAs...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear. METHODS We included 2117 older adults (mean age 65.5 years) enrolled in the Health...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION We systematically characterized plasma protein profiles in cerebral amyloid angiopathy (CAA) using proteomics and identified a hub protein panel for disease diagnosis and risk stratification. METHODS A total of 146 patients with probable CAA and...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract BACKGROUND Heterogeneity in Alzheimer’s disease (AD) progression introduces variability in treatment effect assessments. Using predicted future progression as an AD prognostic covariate (APC) may reduce this variability. This study evaluates this...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION The progressive nature of Alzheimer’s disease (AD) highlights the importance of predicting lifetime risk and updating assessments as new data emerge. This study aimed to develop a dynamic model using longitudinal cognitive assessments for...
