by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma...
by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract INTRODUCTION The social exposome is increasingly recognized as a key determinant for cognitive health. Adverse policing represents an understudied aspect of the social exposome, reflecting persistent encounters with punitive surveillance and law enforcement...
by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia
Abstract INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormalities and longitudinal...
by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia
Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p-tau217) in Alzheimer’s disease (AD) remains uncertain. METHODS In this multi-cohort study of 2117 individuals, we established baseline plasma p-tau217...
by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer’s disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in...
