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Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

by Clinical Neuropsychologist Online | Monday, August 10, 2026 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs remains unclear. METHODS We performed high-quality, sex-balanced single-nucleus RNA sequencing of...

Brain morphometry patterns in the presence of Alzheimer’s disease and/or LATE neuropathologic changes

by Clinical Neuropsychologist Online | Monday, August 10, 2026 | Dementia

Abstract INTRODUCTION Alzheimer’s disease neuropathologic change (ADNC) and limbic-predominant age-related transactive response DNA-binding protein 43 kDa (TDP-43) encephalopathy neuropathologic change (LATENC) are common in older adults, yet differences in...

Multidimensional workplace stressors differentially impact cognitive trajectories

by Clinical Neuropsychologist Online | Monday, August 10, 2026 | Dementia

Abstract INTRODUCTION Little research has assessed detailed occupational exposures in relation to the dementia exposome. We characterized patterns of multidimensional workplace stressors in relation to cognitive trajectories and racial disparities. METHODS We included...

Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults

by Clinical Neuropsychologist Online | Monday, August 10, 2026 | Dementia

Abstract INTRODUCTION Subjective cognitive concerns frequently diverge from objective cognitive performance in cognitively unimpaired (CU) older adults, yet the neurobiological basis of this mismatch remains unclear. METHODS In 648 participants from the Investigating...

Neuromodulatory subcortical systems in Alzheimer’s disease

by Clinical Neuropsychologist Online | Saturday, August 8, 2026 | Dementia

Alzheimer’s &Dementia, Volume 22, Issue 8, August 2026. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | August 8, 2026 Neuro-Dementia Previous...
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