by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Dementia
Abstract INTRODUCTION We evaluated lecanemab’s safety and cognitive outcomes in Chinese patients with Alzheimer’s disease (AD) and the utility of blood-based biomarkers (BBMs) for treatment guidance. METHODS A multicenter, real-world cohort enrolled 1042...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION Animal models demonstrated that pharmacologically-induced lesioning of the locus coeruleus (LC), the brain’s primary source of norepinephrine, triggered astrocyte reactivity, exacerbating Alzheimer’s disease (AD) pathology and...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention. METHODS In the...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION Tooth loss is associated with dementia risk, but mechanisms remain unclear. We examined whether blood-based neurodegenerative biomarkers mediate the edentulism–cognition association. METHODS Among 4238 Health and Retirement Study participants...
by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia
Abstract INTRODUCTION We examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its...
