by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia
Abstract INTRODUCTION Early symptoms in young onset Alzheimer’s disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map adverse occupational events preceding YOAD diagnosis as potential prodromal signs. METHODS...
by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia
Abstract INTRODUCTION We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline. METHODS Eighty-nine non-demented older adults from a Korean cohort...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Isolated REM sleep behavior disorder (iRBD) is a strong prodromal marker of Lewy body diseases (LBDs) – Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Cholinergic loss is linked to cognitive decline in these conditions, but...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers. METHODS We thoroughly investigated...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Human herpesvirus (HHV) has been linked to Alzheimer’s disease (AD), but the underlying mechanisms remain unknown. METHODS We leveraged functional genomics data from Religious Orders Study or the Rush Memory and Aging Project (ROS/MAP) and...
