by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia
Abstract INTRODUCTION Genetic factors contribute to variability in age-related cognitive decline, yet the molecular mechanisms underlying cognitive resilience remain poorly understood. METHODS We performed single-nucleus RNA sequencing on hippocampal tissue from 107...
by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia
Abstract INTRODUCTION Limbic-predominant age-related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE-NC) is common in older adults, yet definitive diagnosis is only possible at autopsy. METHODS This work developed a fully...
by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia
Abstract INTRODUCTION We studied dementia incidence and risk factors in Indigenous Tsimane and Moseten Amerindian populations in Amazonian Bolivia with largely subsistence lifestyles. METHODS A median of 4.7 years after baseline dementia assessment, 730 participants...
by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia
Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer’s disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is...
by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia
Abstract INTRODUCTION Amyloid positivity does not reliably predict near-term cognitive decline in preclinical Alzheimer’s disease (AD). We tested whether digital cognitive phenotyping improves prognostic precision. METHODS Baseline performance on a brief...
