by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract Virtually all people with Down syndrome will develop Alzheimer disease pathology during their lifetime. As Alzheimer disease is the third leading cause of death and a significant factor in end-of-life complications for adults with Down syndrome, identifying...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract We systematically reviewed and meta-analyzed bulk RNA sequencing (RNAseq) studies comparing Alzheimer’s disease (AD) patients to controls in human brain tissue. We searched PubMed, Web of Science, and Scopus for human brain bulk RNAseq studies,...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION Parkinsonism in patients with Alzheimer’s disease (AD) is often attributed to Lewy-related pathology, given its high comorbidity. In the era of anti-amyloid therapy, recognizing parkinsonism caused by AD pathology is needed to optimize the...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) is the leading cause of dementia, affecting around 50 million individuals worldwide. Brain-derived extracellular vesicles (EVs) can cross the blood–brain barrier carrying neuron-specific molecules, such as microRNAs...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear. METHODS We included 2117 older adults (mean age 65.5 years) enrolled in the Health...
