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The social environment and cognitive aging over the life course: laying out critical concepts and research gaps

by Clinical Neuropsychologist Online | Monday, July 13, 2026 | Dementia

Abstract The social environment refers to our interpersonal relations, workplaces, and neighborhoods, towns, or cities in which we live. A growing literature indicates that social environments are related to cognitive aging and risk of Alzheimer’s disease and...

Social network characteristics and cognitive function, decline, and mortality: A joint modeling approach

by Clinical Neuropsychologist Online | Sunday, July 12, 2026 | Dementia

Abstract INTRODUCTION Maintaining social relationships is challenging in advanced old age due to frequent changes in social networks. Little is known about whether social networks are associated with cognitive function, decline, and mortality in this population, or...

Proteomics of post mortem brains in early‐ and late‐onset Alzheimer’s disease: Unraveling differential Aβ effects and potential AD biomarkers

by Clinical Neuropsychologist Online | Sunday, July 12, 2026 | Dementia

Abstract BACKGROUND Alzheimer’s disease (AD) occurs primarily as late‑onset (LOAD) and less frequently as early‑onset (EOAD). Its defining pathologies are hyperphosphorylated tau tangles and amyloid beta (Aβ) plaques. METHODS We analyzed the proteomes of 115...

Depressive symptom instability predicts incident mild cognitive impairment and dementia in older adults

by Clinical Neuropsychologist Online | Sunday, July 12, 2026 | Dementia

Abstract INTRODUCTION Neuropsychiatric symptoms frequently precede Alzheimer’s disease and related dementias, yet risk prediction models typically rely on baseline depression severity or diagnostic status. We examined whether instability in depressive symptoms...

Nuclear dysfunction in aging and neurodegeneration

by Clinical Neuropsychologist Online | Sunday, July 12, 2026 | Dementia

Abstract Neurodegenerative diseases are characterized by a loss of neuronal function and structure, often in a region-specific manner. Multiple factors contribute to neuronal dysfunction and death, including pathogenic protein buildup, protein mislocalization, and...
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