by Clinical Neuropsychologist Online | Tuesday, October 6, 2026 | Dementia
Abstract BACKGROUND Late-onset Alzheimer’s disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell-type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell-based polygenic risk scores (cbPRSs)...
by Clinical Neuropsychologist Online | Tuesday, October 6, 2026 | Dementia
Abstract INTRODUCTION The clusterin gene (CLU) is a top genome-wide association studies (GWAS) risk locus for Alzheimer’s disease (AD) and elevated clusterin levels have been reported in AD biofluids and brain tissue. Despite growing interest in clusterin as a...
by Clinical Neuropsychologist Online | Monday, October 5, 2026 | Dementia
Abstract INTRODUCTION Early neurofibrillary tau degeneration in the entorhinal cortex (EC) is a hallmark of Alzheimer’s disease (AD) and aging. We propose a biomechanical cascade hypothesis, suggesting proximity to the tentorial incisura (TI) may render the EC...
by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Plasma high-density lipoprotein (HDL) varies in size. We examined the associations between HDL subclasses and their lipid composition and incident dementia risk in older adults. METHODS We included 23,790 United Kingdom (UK) Biobank (UKB) and 147...
by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Metabolic stress increases Alzheimer’s disease (AD) risk, but mechanisms linking metabolic dysfunction to neuroimmune dysregulation remain unclear. METHODS We assessed cognition in community-dwelling participants and used high-fat diet...
