by Clinical Neuropsychologist Online | Monday, October 26, 2026 | Dementia
Abstract INTRODUCTION Dementia with Lewy bodies (DLB) is a common but underdiagnosed neurodegenerative disease associated with α-synuclein pathology. Clinically, DLB is characterized by early motor dysfunction and psychiatric symptoms, in contrast to early memory...
by Clinical Neuropsychologist Online | Monday, October 26, 2026 | Dementia
Abstract Sleep disturbances are highly prevalent in older adults and are particularly common among individuals attending memory clinics for assessment of cognitive impairment. Emerging evidence links sleep disorders, including insomnia, obstructive sleep apnea,...
by Clinical Neuropsychologist Online | Sunday, October 25, 2026 | Dementia
Abstract INTRODUCTION 18F-MK6240 is a second-generation tau positron emission tomography (PET) tracer with high dynamic range able to detect early tau pathology in Alzheimer’s disease, however, its binding characteristics have not been evaluated in Down syndrome...
by Clinical Neuropsychologist Online | Sunday, October 25, 2026 | Dementia
Abstract INTRODUCTION Lifestyle and environmental factors contributing to cardiovascular risk are components of the exposome, yet molecular signatures associated with cumulative cardiovascular risk in Alzheimer’s disease (AD) remain incompletely understood....
by Clinical Neuropsychologist Online | Sunday, October 25, 2026 | Dementia
Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation,...
