by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Excitation–inhibition (E/I) imbalance has been proposed as an early circuit-level mechanism in Alzheimer’s disease (AD), but its relationship to molecular pathology and cognition in humans remains unclear. METHODS We integrated biophysical...
by Clinical Neuropsychologist Online | Wednesday, September 30, 2026 | Dementia
Abstract INTRODUCTION Environmental exposures contribute substantially to Alzheimer’s disease and related dementias (ADRD), yet comprehensive exposome-wide investigations systematically evaluating multi-domain environmental factors remain limited and lacking...
by Clinical Neuropsychologist Online | Tuesday, September 29, 2026 | Dementia
Dementia, Ahead of Print. In the context of global demographic change, the number of patients with Alzheimer’s disease (AD) and other forms of dementia is steadily increasing. These individuals require ongoing care but often struggle to communicate their needs and...
by Clinical Neuropsychologist Online | Monday, September 28, 2026 | Dementia
Abstract External exposome research offers opportunities to evaluate complex relationships between multiple environmental determinants of Alzheimer’s disease and related dementias (ADRD). However, selecting specific exposure domains, identifying metrics, and...
by Clinical Neuropsychologist Online | Monday, September 28, 2026 | Dementia
Abstract BACKGROUND The APOE ε4 allele has weaker association with ADRD outcomes in Hispanic/Latino populations compared to non-Hispanic White and East Asian populations. METHODS We used whole-genome sequencing data from 13,025 Hispanic/Latino adults to infer...
