by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION We systematically characterized plasma protein profiles in cerebral amyloid angiopathy (CAA) using proteomics and identified a hub protein panel for disease diagnosis and risk stratification. METHODS A total of 146 patients with probable CAA and...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract BACKGROUND Heterogeneity in Alzheimer’s disease (AD) progression introduces variability in treatment effect assessments. Using predicted future progression as an AD prognostic covariate (APC) may reduce this variability. This study evaluates this...
by Clinical Neuropsychologist | Wednesday, March 5, 2025 | Dementia
Abstract INTRODUCTION The progressive nature of Alzheimer’s disease (AD) highlights the importance of predicting lifetime risk and updating assessments as new data emerge. This study aimed to develop a dynamic model using longitudinal cognitive assessments for...
by Clinical Neuropsychologist | Friday, February 28, 2025 | Dementia
Abstract INTRODUCTION Human tau protein, composed of six brain-specific isoforms, is a major driver of Alzheimer’s disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout...
by Clinical Neuropsychologist | Thursday, February 27, 2025 | Dementia
Dementia, Ahead of Print. ObjectiveThe study’s aim was to better understand how persons, diagnosed with dementia while still working, strived to make sense of and come to terms with their changing everyday lives during the process of exiting work life.MethodsThe study...
