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Performance of study partner reports in a non‐demented at‐risk sample

by Clinical Neuropsychologist Online | Wednesday, February 26, 2025 | Dementia

Abstract INTRODUCTION The Clinical Dementia Rating (CDR) Scale is a gold standard for staging impairment in Alzheimer’s disease and other dementias (ADRD). The Quick Dementia Rating System (QDRS) offers similar results in 3 to 5 minutes without a trained...

Plasma Alzheimer’s disease biomarker relationships with incident abnormal amyloid PET

by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Limited data exist on the utility of plasma biomarkers to predict incident abnormal amyloid positron emission tomography (PET). In this study we evaluate the association of plasma Alzheimer’s disease (AD) biomarkers with amyloid PET...

Physical activity may protect myelin via modulation of high‐density lipoprotein

by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied....

Tau‐related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is influenced by Aβ

by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Positron emission tomography (PET) imaging studies have shown that amyloid beta (Aβ) is significantly correlated with glucose metabolism in mild cognitive impairment independently of the apolipoprotein E (APOE) ε4 genotype. METHODS We used a...

Characterizing the olfaction and dementia association in the community‐based ARIC study

by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Few studies have characterized the association of olfaction with dementia in detail across diverse sociodemographic subgroups. METHODS We examined the association of one-time-point olfactory status with incident dementia overall and by age, race,...
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