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SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes

by Clinical Neuropsychologist | Wednesday, October 30, 2024 | Dementia

Abstract INTRODUCTION We investigated hippocampal synaptic density using synaptic vesicle 2A positron emission tomography (PET), and its association with amyloid beta (Aβ) and cognitive performance in healthy apolipoprotein E (APOE) ε4 carriers. METHODS Synaptic...

Neurophysiological biomarkers of Alzheimer’s disease: In vivo evaluation of synaptic dysfunction

by Clinical Neuropsychologist | Tuesday, October 29, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Francesco Motolese, Raffaele Dubbioso, Federico Ranieri,...

2024 AA criteria for Alzheimer’s disease diagnosis: Mainly anchored at Aβ not tau

by Clinical Neuropsychologist | Tuesday, October 29, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Alexis Moscoso, Nicolas Villain | October 29, 2024 Wiley:...

Latent change‐on‐change between amyloid accumulation and cognitive decline

by Clinical Neuropsychologist | Tuesday, October 29, 2024 | Dementia

Abstract INTRODUCTION While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored. METHODS A series of bivariate latent change score models...

A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline

by Clinical Neuropsychologist | Tuesday, October 29, 2024 | Dementia

Abstract BACKGROUND The Everyday Cognition scale (ECog-39) scores are associated with future cognitive decline. We investigated whether the 12-item ECog (ECog-12), which is being collected in Alzheimer’s Disease Neuroimaging Initiative (ADNI)4, can predict...
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