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Integrated cerebellar radiomic‐network model for predicting mild cognitive impairment in Alzheimer’s disease

by Clinical Neuropsychologist | Wednesday, November 13, 2024 | Dementia

Abstract INTRODUCTION Pathological and neuroimaging alterations in the cerebellum of Alzheimer’s disease (AD) patients have been documented. However, the role of cerebellum-derived radiomic and structural connectome modeling in the prediction of AD progression...

Large‐scale deep proteomic analysis in Alzheimer’s disease brain regions across race and ethnicity

by Clinical Neuropsychologist | Wednesday, November 13, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non-Hispanic White (NHW) populations. Here we provide an extensive survey of the proteomic landscape of...

The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down’s syndrome

by Clinical Neuropsychologist | Wednesday, November 13, 2024 | Dementia

Abstract INTRODUCTION Development of Alzheimer’s disease (AD) pathology in Down’s syndrome (DS) occurs within a compressed timeline compared to sporadic or other genetic forms of AD. METHODS Plasma glial fibrillary acidic protein (GFAP) and plasma pTau-217...

Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions

by Clinical Neuropsychologist | Wednesday, November 13, 2024 | Dementia

Abstract White matter hyperintensities (WMH) and infarcts found on magnetic resonance imaging (MR infarcts) are common biomarkers of cerebrovascular disease. In this review, we summarize the methods, publications, and conclusions stemming from the Alzheimer’s...

Sex‐specific topological structure associated with dementia via latent space estimation

by Clinical Neuropsychologist | Tuesday, November 12, 2024 | Dementia

Abstract INTRODUCTION We investigate sex-specific topological structures associated with typical Alzheimer’s disease (AD) dementia using a novel state-of-the-art latent space estimation technique. METHODS This study applies a probabilistic approach for latent...
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