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Brexpiprazole treatment for agitation in Alzheimer’s dementia: A randomized study

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Abstract INTRODUCTION We evaluated the efficacy and safety of brexpiprazole for the treatment of agitation in Alzheimer’s dementia (AAD) in Japanese patients. METHODS This was a phase 2/3 multicenter, randomized, double-blind, placebo-controlled, parallel-group...

Need to adapt Alzheimer’s disease criteria in Latin America

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Nilton Custodio, Ricardo Allegri, Francisco Lopera, Paulo...

Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Abstract INTRODUCTION People with neurodegenerative disorders (ND) frequently face diagnostic delay and misdiagnosis. We investigated blood and cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric disorders (PPD), a...

Argentina–Alzheimer’s Disease Neuroimaging Initiative: pioneering Alzheimer’s Research in Latin America and its Implications for Regional Advancement

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Abstract The Alzheimer’s Disease Neuroimaging Initiative (ADNI) has fostered collaboration among researchers around the world, catalyzing innovation and accelerating progress in the field. In Latin America, this initiative advanced the validation and development...

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy

by Clinical Neuropsychologist | Sunday, October 6, 2024 | Dementia

Abstract INTRODUCTION It is unclear how early neuronal deficits occur in tauopathies, if these are associated with changes in neuronal network activity, and if they can be alleviated with therapies. METHODS To address this, we performed in vivo two-photon Ca2+ imaging...
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