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Morphometry of medial temporal lobe subregions using high‐resolution T2‐weighted MRI in ADNI3: Why, how, and what’s next?

by Clinical Neuropsychologist | Monday, September 16, 2024 | Dementia

Abstract This paper for the 20th anniversary of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) provides an overview of magnetic resonance imaging (MRI) of medial temporal lobe (MTL) subregions in ADNI using a dedicated high-resolution T2-weighted...

Cognitive assessment of nursing home residents: Survey data on tools used and perceptions of use among social service professionals in one U.S. state

by Clinical Neuropsychologist | Saturday, September 14, 2024 | Dementia

Dementia, Volume 24, Issue 3, Page 424-435, April 2025. Background:Social service professionals routinely use screening tools to assess for cognitive decline or identify suspected dementia in nursing home residents. Published literature lacks details about the...

Combining cerebrospinal fluid and PI‐2620 tau‐PET for biomarker‐based stratification of Alzheimer’s disease and 4R‐tauopathies

by Clinical Neuropsychologist | Thursday, September 12, 2024 | Dementia

Abstract INTRODUCTION Recent advances in biomarker research have improved the diagnosis and monitoring of Alzheimer’s disease (AD), but in vivo biomarker-based workflows to assess 4R-tauopathy (4RT) patients are currently missing. We suggest a novel...

Cognitive resilience to Alzheimer’s disease characterized by cell‐type abundance

by Clinical Neuropsychologist | Thursday, September 12, 2024 | Dementia

Abstract INTRODUCTION The molecular basis of cognitive resilience (CR) among pathologically confirmed Alzheimer’s disease (AD) cases is not well understood. METHODS Abundance of 13 cell types and neuronal subtypes in brain bulk RNA-seq data from the anterior...

Detection of sex‐specific glutamate changes in subregions of hippocampus in an early‐stage Alzheimer’s disease mouse model using GluCEST MRI

by Clinical Neuropsychologist | Thursday, September 12, 2024 | Dementia

Abstract INTRODUCTION Regional glucose hypometabolism resulting in glutamate loss has been shown as one of the characteristics of Alzheimer’s disease (AD). Because the impact of AD varies between the sexes, we utilized glutamate-weighted chemical exchange...
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