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Neighborhood disadvantage and the incidence of dementia in US Black women

by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia

Abstract INTRODUCTION We investigated the association of neighborhood disadvantage with the incidence of Alzheimer’s disease and related dementias (ADRD) in the longitudinal Black Women’s Health Study (BWHS). METHODS The study included 10,915 BWHS...

Deciding on genetic testing for familial dementia: Perspectives of patients and families

by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia

Abstract INTRODUCTION We explored patients’ and families’ interest in, predictors of, and considerations regarding genetic testing for monogenic causes of dementia in a diagnostic setting. METHODS This mixed-methods study evaluated 519 consecutive Alzheimer Center...

Addressing overfitting bias due to sample overlap in polygenic risk scoring

by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia

Abstract INTRODUCTION Numerous studies on Alzheimer’s disease polygenic risk scores (PRSs) overlook sample overlap between International Genomics of Alzheimer’s Project (IGAP) and target datasets like Alzheimer’s Disease Neuroimaging Initiative...

Quantification of perforant path fibers for early detection of Alzheimer’s disease

by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia

Abstract INTRODUCTION The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer’s disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of...

Exposure to neighborhood concentrated poverty is associated with faster decline in episodic memory among midlife women

by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia

Abstract INTRODUCTION Neighborhood-level socioeconomic status (nSES) is associated with risk for cognitive impairment, but prior studies assessed nSES within an individual’s own residential area without considering the distribution of nSES among adjacent areas....
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