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The use of photovoice to explore the physical disability experience in older adults with mild cognitive impairment/early dementia

by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia

Dementia, Volume 24, Issue 1, Page 40-70, January 2025. Although co-occurring cognitive impairment and physical disability in older adults is common, there is little understanding of how this group perceives their ability to do their daily activities. This study used...

Spatial and temporal patterns of cortical mean diffusivity in Alzheimer’s disease and suspected non‐Alzheimer’s disease pathophysiology

by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia

Abstract INTRODUCTION The spatial and temporal patterns of cortical mean diffusivity (cMD), as well as its association with Alzheimer’s disease (AD) and suspected non-Alzheimer’s pathophysiology (SNAP), are not yet fully understood. METHODS We compared...

Air pollution amyloidogenesis is attenuated by the gamma‐secretase modulator GSM‐15606

by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia

Abstract INTRODUCTION Chronic air pollution (AirPoll) is associated with accelerated cognitive decline and risk of Alzheimer’s disease (AD). Correspondingly, wild-type and AD-transgenic rodents exposed to AirPoll have increased amyloid peptides and behavioral...

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age

by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia

Abstract INTRODUCTION We investigated the associations of leptin markers with cognitive function and magnetic resonance imaging (MRI) measures of brain atrophy and vascular injury in healthy middle-aged adults. METHODS We included 2262 cognitively healthy participants...

Psychosocial implications of learning amyloid PET results in an observational cohort

by Clinical Neuropsychologist | Monday, August 12, 2024 | Dementia

Abstract INTRODUCTION Information on the psychosocial impact of Alzheimer’s disease (AD) biomarker testing in adults at risk of AD is needed to inform best practices for communicating biomarker results. METHODS Ninety-nine cognitively unimpaired older adults...
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