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Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

by Clinical Neuropsychologist | Thursday, March 19, 2026 | Neuroscience

Nature Neuroscience, Published online: 19 March 2026; doi:10.1038/s41593-026-02208-0Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that...

Cortical regulation of collective social dynamics during environmental challenge

by Clinical Neuropsychologist | Wednesday, March 18, 2026 | Neuroscience

Nature Neuroscience, Published online: 18 March 2026; doi:10.1038/s41593-026-02224-0Raam, Li, Gu and colleagues identify neural mechanisms underlying group huddling in mice during cold exposure. They find that the prefrontal cortex encodes decisions to huddle and that...

Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia

by Clinical Neuropsychologist | Wednesday, March 18, 2026 | Neuroscience

Nature Neuroscience, Published online: 18 March 2026; doi:10.1038/s41593-026-02237-9Zhou, Ho and colleagues show that, in mice, a schizophrenia-associated mutation impairs belief updating by weakening mediodorsal (MD) thalamus activity. Boosting this activity restored...

Mapping deep brain stimulation-modulated circuits via precision neuroimaging

by Clinical Neuropsychologist | Wednesday, March 18, 2026 | Neuroscience

Nature Neuroscience, Published online: 18 March 2026; doi:10.1038/s41593-026-02229-9Precision neuroimaging of repeatedly scanned individuals receiving deep brain stimulation (DBS), conducted longitudinally with long scanning durations, revealed separate globus...

Organization of neuropeptide systems in the human brain

by Clinical Neuropsychologist | Tuesday, March 17, 2026 | Neuroscience

Nature Neuroscience, Published online: 17 March 2026; doi:10.1038/s41593-026-02236-wThis study comprehensively maps neuropeptide systems in the human brain to elucidate their organizational principles and shows how neuropeptide architecture is linked to behavior and...
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