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Serotonergic modulation of the BNST–CeA pathway reveals sex differences in fear learning

by Clinical Neuropsychologist | Wednesday, August 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 August 2025; doi:10.1038/s41593-025-02025-xRavenelle et al. show that systematically increasing serotonin has sex-specific effects on fear learning in mice. In females only, increasing serotonin in the BNST enhances fear...

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

by Clinical Neuropsychologist | Wednesday, August 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 August 2025; doi:10.1038/s41593-025-02010-4Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed...

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

by Clinical Neuropsychologist | Monday, August 4, 2025 | Neuroscience

Nature Neuroscience, Published online: 04 August 2025; doi:10.1038/s41593-025-02021-1Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT2AR activation without immediately...

Alzheimer’s disease transcriptional landscape in ex vivo human microglia

by Clinical Neuropsychologist | Monday, August 4, 2025 | Neuroscience

Nature Neuroscience, Published online: 04 August 2025; doi:10.1038/s41593-025-02020-2Here the authors provide a comprehensive transcriptomic dataset of human primary microglia for Alzheimer’s disease and healthy aging. They identify dysregulation of immune-related...

Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind

by Clinical Neuropsychologist | Wednesday, July 30, 2025 | Neuroscience

Nature Neuroscience, Published online: 30 July 2025; doi:10.1038/s41593-025-02015-zDifferences in neuroeconomic decision-making influence nucleus accumbens dopamine dynamics and reflect choice confidence during evaluation, as well as past and future value during...
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