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Genome-wide analysis of common structural variants in Alzheimer’s disease identifies a risk-associated regulatory CCG repeat in FAM193B

by Clinical Neuropsychologist Online | Monday, October 12, 2026 | Neuroscience

Nature Neuroscience, Published online: 12 October 2026; doi:10.1038/s41593-026-02481-zThis study identifies common structural variants contributing to Alzheimer’s disease heritability. An expanded promoter CCG repeat increases FAM193B expression and disease risk,...

Investigating molecular and hemodynamic effects of LSD in the human brain

by Clinical Neuropsychologist Online | Monday, October 12, 2026 | Neuroscience

Nature Neuroscience, Published online: 12 October 2026; doi:10.1038/s41593-026-02462-2Using simultaneous PET–MRI, McCulloch, Larsen and colleagues quantify LSD’s dose–occupancy relationship at the serotonin 2A receptor and reveal hemodynamic effects of LSD that...

Alus harbor genetic variants that shape the human cortex

by Clinical Neuropsychologist Online | Monday, October 12, 2026 | Neuroscience

Nature Neuroscience, Published online: 12 October 2026; doi:10.1038/s41593-026-02492-wThe genetic changes associated with development of the human cortex are difficult to test functionally, especially in the context of gene regulation. In this issue, Matoba et al....

Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data

by Clinical Neuropsychologist Online | Thursday, October 8, 2026 | Neuroscience

Nature Neuroscience, Published online: 08 October 2026; doi:10.1038/s41593-026-02472-0Hou et al. show a drug target compendium supported by human genetic and real-world patient data for Alzheimer’s disease and validate epoxide hydrolase 2 as a causal Alzheimer’s...

Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons

by Clinical Neuropsychologist Online | Wednesday, October 7, 2026 | Neuroscience

Nature Neuroscience, Published online: 07 October 2026; doi:10.1038/s41593-026-02464-0Astrocytes regulate axonal mitochondrial transport in motor neurons through mitochondrial bioenergetics, a process disrupted in C9ORF72-mediated amyotrophic lateral sclerosis....
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