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Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges

by Clinical Neuropsychologist Online | Thursday, April 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02258-4High-density single-neuron recordings in patients with epilepsy revealed interictal discharges are generated by structured laminar circuits. These circuits overlapped with cognitive...

Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation

by Clinical Neuropsychologist Online | Thursday, April 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02263-7The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with...

Down the Rashomon Hole: Reflections on Mapping Emotions in the Brain

by Clinical Neuropsychologist Online | Wednesday, April 29, 2026 | Neuroscience

CNS 2026 guest post by Mohith (Mo) M. Varma Sitting through the four talks at the “Mapping Emotions in the Brain” symposium at the CNS 2026 annual meeting, I couldn’t shake the feeling I was watching the scientific equivalent of Rashomon, Akira Kurosawa’s 1950...

A septo–entorhinal GABAergic pathway that enables switching between episodic memories

by Clinical Neuropsychologist Online | Wednesday, April 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 April 2026; doi:10.1038/s41593-026-02280-6How the brain organizes the retrieval of old and new memories remains unknown. Kim et al. identify a septo−entorhinal GABAergic pathway that controls flexible switching between...

Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus

by Clinical Neuropsychologist Online | Tuesday, April 28, 2026 | Neuroscience

Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02253-9The authors investigate the transcriptomic and connectivity organization of the basal ganglia and parafascicular nucleus. The analyses suggest that combinatorial gene expression...
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