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Constituent-constrained word prediction during language comprehension

by Clinical Neuropsychologist Online | Tuesday, April 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02272-6Zou et al. reveal a key difference between human brains and large language models (LLMs). While LLMs are optimized to predict the next word, the human brain modulates prediction...

Genomic approaches for understanding the evolution of the human brain

by Clinical Neuropsychologist Online | Tuesday, April 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02277-1This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive...

Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe

by Clinical Neuropsychologist Online | Thursday, April 16, 2026 | Neuroscience

Nature Neuroscience, Published online: 16 April 2026; doi:10.1038/s41593-026-02256-6The authors characterized the spatial origin of Drosophila medulla neurons, completing their previous characterization of the temporal and Notch origins of these neurons and allowing...

Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities

by Clinical Neuropsychologist Online | Thursday, April 16, 2026 | Neuroscience

Nature Neuroscience, Published online: 16 April 2026; doi:10.1038/s41593-026-02265-5Integrating spatial and single-cell data from 100 patients, the authors define conserved cellular communities and communications in glioblastoma, revealing distinct mesenchymal-like...

Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol

by Clinical Neuropsychologist Online | Wednesday, April 15, 2026 | Neuroscience

Nature Neuroscience, Published online: 15 April 2026; doi:10.1038/s41593-026-02261-9This study uncovers how amyloid-β boosts astrocyte calcium activity, increasing cholesterol and disrupting brain waste clearance in an Alzheimer’s disease mouse model. Targeting...
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