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Single-cell multi-omic atlas and morphogen screening informs midbrain and hindbrain organoid engineering

by Clinical Neuropsychologist Online | Wednesday, June 3, 2026 | Neuroscience

Nature Neuroscience, Published online: 03 June 2026; doi:10.1038/s41593-026-02316-xBy combining single-cell sequencing and morphogen screening, researchers map how signaling cues shape cell identity in mid-hindbrain organoids and identify conditions that generate...

Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility

by Clinical Neuropsychologist Online | Tuesday, June 2, 2026 | Neuroscience

Nature Neuroscience, Published online: 02 June 2026; doi:10.1038/s41593-026-02321-0This study shows that androgens signal to specific enteric neurons to stimulate gut motility. Bacterial metabolism of host-derived steroids generates the ligands, revealing a dynamic...

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02301-4In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism...

Why pain biomarkers cannot replace the patient experience

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02324-xUsing neuroimaging to understand the mechanisms of pain is an important task. But we must understand that the gold standard of measuring pain will always be the self-report. If you do...

Towards a holistic understanding of pain in the biomarker age

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02323-yPain biomarkers cannot prove or disprove another person’s pain, but they need not be rejected as futile or reductionist. When developed within a bio-psycho-social framework and guided...
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