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cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy

by Clinical Neuropsychologist Online | Wednesday, July 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 July 2026; doi:10.1038/s41593-026-02384-zHuang et al. found that stressed neurons release DNA that activates the immune sensor cGAS, driving inflammatory responses that worsen seizures and mortality in Dravet syndrome....

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, July 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 July 2026; doi:10.1038/s41593-026-02390-1Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they...

Experience reorganizes content-specific memory traces in macaques

by Clinical Neuropsychologist Online | Wednesday, July 29, 2026 | Neuroscience

Nature Neuroscience, Published online: 29 July 2026; doi:10.1038/s41593-026-02357-2In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep...

Replay of procedural memory is independent of the hippocampus

by Clinical Neuropsychologist Online | Thursday, July 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02362-5Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior...

Focal astrocyte loss reveals nuclear translocation during lesion repopulation

by Clinical Neuropsychologist Online | Thursday, July 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02354-5Herwerth et al. demonstrate that, after focal astrocyte loss in the adult brain, perilesional astrocytes undergo extensive remodeling, proliferation and nuclear translocation to...
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