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Serotonin signaling enhances phagocytosis by brain macrophages through Htr2b and alleviates brain injury after stroke

by Clinical Neuropsychologist Online | Wednesday, October 28, 2026 | Neuroscience

Nature Neuroscience, Published online: 28 October 2026; doi:10.1038/s41593-026-02482-yThe serotonin receptor Htr2b activation enhances lysosome biogenesis and phagocytic clearance of debris to mitigate neuroinflammation and brain injury after stroke. The study...

Circuit mechanisms for disentangled representations and generalization in the hippocampus

by Clinical Neuropsychologist Online | Tuesday, October 27, 2026 | Neuroscience

Nature Neuroscience, Published online: 27 October 2026; doi:10.1038/s41593-026-02491-xThe hippocampus encodes different aspects of experience as disentangled variables, enabling flexible recombination and generalization to new situations. This code is supported by the...

Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success

by Clinical Neuropsychologist Online | Tuesday, October 27, 2026 | Neuroscience

Nature Neuroscience, Published online: 27 October 2026; doi:10.1038/s41593-026-02493-9The study shows that stimulus-specific neurons in the human amygdala determine which experiences become lasting memory, revealing a mechanism that predicts episodic memory formation...

Microglial NUS1 deficiency drives dopaminergic neurodegeneration through intercellular iron dysregulation in Parkinson’s disease models

by Clinical Neuropsychologist Online | Monday, October 26, 2026 | Neuroscience

Nature Neuroscience, Published online: 26 October 2026; doi:10.1038/s41593-026-02499-3Using cellular and mouse models, this study reports that deficiency of the Parkinson’s disease risk gene NUS1 in microglia disrupts intercellular iron homeostasis, leading to...

Chronic progressive demyelination induces a microglial state with lysosomal dysfunction

by Clinical Neuropsychologist Online | Monday, October 26, 2026 | Neuroscience

Nature Neuroscience, Published online: 26 October 2026; doi:10.1038/s41593-026-02489-5Acute myelin injury responses are well defined, but microglia adaptations to chronic damage remain unclear. Mouse models reveal a chronic demyelination-associated microglial state...
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