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Dimensionality reduction beyond neural subspaces with slice tensor component analysis

by Clinical Neuropsychologist | Monday, May 6, 2024 | Neuroscience

Nature Neuroscience, Published online: 06 May 2024; doi:10.1038/s41593-024-01626-2Neural activity does not always lie in a low-dimensional subspace. The authors extend this classic view to show that task-relevant information is distributed across multiple...

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

by Clinical Neuropsychologist | Monday, May 6, 2024 | Neuroscience

Nature Neuroscience, Published online: 06 May 2024; doi:10.1038/s41593-024-01634-2Brain tissue from patients with focal cortical dysplasia type II (FCDII) exhibits dysmorphic neurons bearing hallmarks of senescence. Treatment with a senolytic drug reduces seizures in...

Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

by Clinical Neuropsychologist | Wednesday, May 1, 2024 | Neuroscience

Nature Neuroscience, Published online: 01 May 2024; doi:10.1038/s41593-024-01633-3This paper shows that compulsive-like grooming in Sapap3-knockout mice can be reduced by closed-loop optogenetic stimulation of striatal interneurons based on grooming onset prediction,...

Two common and distinct forms of variation in human functional brain networks

by Clinical Neuropsychologist | Tuesday, April 30, 2024 | Neuroscience

Nature Neuroscience, Published online: 30 April 2024; doi:10.1038/s41593-024-01618-2The layout of cortical systems varies across people, which is assumed to be largely due to border shifts between nearby systems. Dworetsky et al. reveal a qualitatively different...

Unsupervised restoration of a complex learned behavior after large-scale neuronal perturbation

by Clinical Neuropsychologist | Monday, April 29, 2024 | Neuroscience

Nature Neuroscience, Published online: 29 April 2024; doi:10.1038/s41593-024-01630-6What mechanisms enable brains to maintain behaviors after neuron loss? Based on behavioral, neuronal and modeling data, Wang et al. find that unsupervised cellular and systems-level...
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