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Flipping APOE to reverse Alzheimer’s disease traits

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02108-9In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo ‘switching’ from the Alzheimer’s risk gene APOE4 to the protective gene APOE2. This...

Unanswered Questions About the Human Brain

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Even after decades of groundbreaking research, the human brain ;remains only ;partially understood. Fundamental questions persist about consciousness, cognition, memory, and neural plasticity. As neuroscience integrates with fields like AI and genetics, we continue to...

Subsecond dopamine fluctuations do not specify the vigor of ongoing actions

by Clinical Neuropsychologist | Monday, November 10, 2025 | Neuroscience

Nature Neuroscience, Published online: 10 November 2025; doi:10.1038/s41593-025-02102-1Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the dorsal...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease

by Clinical Neuropsychologist | Thursday, November 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 November 2025; doi:10.1038/s41593-025-02103-0Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive...

Selective direct influence of motor cortex on limb muscle activity during naturalistic climbing in mice

by Clinical Neuropsychologist | Thursday, November 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 November 2025; doi:10.1038/s41593-025-02093-zKoh, Ma et al. show that during climbing, mouse motor cortex instructs limb muscle activity patterns primarily by selectively activating certain muscles at certain activity states,...
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