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Low-dimensional population dynamics in the brainstem gate REM sleep

by Clinical Neuropsychologist Online | Monday, May 25, 2026 | Neuroscience

Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02314-zLozano et al. show that REM sleep is gated by low-dimensional brainstem network dynamics, in which opposing neuron populations across the midbrain and pons determine when transitions...

Foamy microglia link oxylipins to disease progression in multiple sclerosis

by Clinical Neuropsychologist Online | Thursday, May 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 May 2026; doi:10.1038/s41593-026-02302-3Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and...

Why Brain Lipids Matter: The Hidden Players in Brain Health

by Clinical Neuropsychologist Online | Wednesday, May 20, 2026 | Neuroscience

Migraine – a particular type of headache that can come with visual, sensory, and other symptoms—; strikes one in seven people worldwide. Researchers believe that migraine symptoms are caused by ;neurogenic ;inflammation along with vascular changes in the brain, but...

Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death

by Clinical Neuropsychologist Online | Wednesday, May 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02299-9Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1...

Considering biological limitations of lesion network mapping

by Clinical Neuropsychologist Online | Wednesday, May 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02319-8Lesion network mapping (LNM), or atrophy network mapping, has become a widely adopted tool for linking focal brain lesions or neurodegenerative brain clusters, respectively, to...
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