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Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo

by Clinical Neuropsychologist Online | Friday, April 24, 2026 | Neuroscience

Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02247-7By studying 23 neurodevelopmental disorder genes across model systems and brain cell types, the authors uncovered shared downstream effects that converge on synaptic biology,...

Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, April 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02260-wThe authors reveal entorhinal cortex dopaminergic and behavioral dysfunction in Alzheimer’s model mice, suggesting the possibility that entorhinal dopamine loss may contribute to...

BOLD fMRI reflects both vascular and metabolic signals

by Clinical Neuropsychologist Online | Thursday, April 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02288-yA recent study by Epp et al. uses advanced, quantitative functional MRI measures to demonstrate that the ‘canonical’ interpretation of blood-oxygenation-level-dependent (BOLD)...

Constituent-constrained word prediction during language comprehension

by Clinical Neuropsychologist Online | Tuesday, April 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02272-6Zou et al. reveal a key difference between human brains and large language models (LLMs). While LLMs are optimized to predict the next word, the human brain modulates prediction...

Genomic approaches for understanding the evolution of the human brain

by Clinical Neuropsychologist Online | Tuesday, April 21, 2026 | Neuroscience

Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02277-1This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive...
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