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Tau pathology in mouse spinal neurons underlies early touch loss and heralds cognitive decline

by Clinical Neuropsychologist | Thursday, November 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 November 2025; doi:10.1038/s41593-025-02138-3Early tactile deficits in patients with Alzheimer disease (AD) and AD mouse models map to tau pathology in spinal cholecystokinin (CCK) neurons. In AD mice, reducing tau or c-Maf...

Author Correction: Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity

by Clinical Neuropsychologist | Wednesday, November 19, 2025 | Neuroscience

Nature Neuroscience, Published online: 19 November 2025; doi:10.1038/s41593-025-02172-1Author Correction: Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity If you do not see content above, kindly GO TO SOURCE. Not all publishers...

Brain-wide analysis reveals movement encoding structured across and within brain areas

by Clinical Neuropsychologist | Tuesday, November 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 November 2025; doi:10.1038/s41593-025-02114-xUsing a large dataset of neural recordings and modern video-analysis methods, Wang, Kurgyis et al. describe a rich, structured encoding of movement across and within brain areas in...

Neural basis of concurrent deliberation toward a choice and confidence judgment

by Clinical Neuropsychologist | Tuesday, November 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 November 2025; doi:10.1038/s41593-025-02116-9Confidence is key to decision-making, but the dynamics of confidence formation remain elusive. We show that neural populations in parietal cortex reflect the parallel processes of...

Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons

by Clinical Neuropsychologist | Tuesday, November 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 November 2025; doi:10.1038/s41593-025-02137-4This study reveals how Tau pathology in spinal neurons contributes to early tactile deficits in Alzheimer’s disease, linking sensory dysfunction to cognitive decline. It highlights...
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