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Japan‐Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial

by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia

Abstract INTRODUCTION We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI). METHODS Participants aged 65-85 years with MCI were randomized into intervention (management...

Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease

by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia

Abstract INTRODUCTION We investigate pathological correlates of plasma phosphorylated tau 181 (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) across a clinically diverse spectrum of neurodegenerative disease, including normal...

Cortical microinfarcts in adults with Down syndrome assessed with 3T‐MRI

by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia

Abstract BACKGROUND Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS We included 195 adults...

Factors associated with pain intensity and analgesic use during inpatient rehabilitation for hip fracture.

by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Neurorehabilitation

Rehabilitation Psychology, Vol 70(1), Feb 2025, 46-54; doi:10.1037/rep0000560Purpose: Effective pain management is vital for hip fracture recovery, yet the factors influencing pain reporting and pain medication use during inpatient rehabilitation for hip fractures are...

Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia

by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 April 2024; doi:10.1038/s41593-024-01624-4Gene expression in the human cortex is shown to involve three general components, which reflect metabolic and immune programs of healthy development, and link case–control imaging and...
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