Heterogeneity in plasma p‐tau217 response and its association with cognitive trajectories under lecanemab treatment

by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia

Abstract INTRODUCTION Plasma phosphorylated tau 217 (p-tau217) is a promising biomarker for monitoring treatment response in Alzheimer’s disease (AD), but its longitudinal dynamics and clinical relevance remain unclear. METHODS In this prospective real-world...

Evaluating digital cognitive tests for clinical use in Alzheimer’s disease: A novel framework and scoping review

by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia

Abstract Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease (AD), remains undiagnosed in > 90% of individuals, delaying access to timely evaluation and interventions. Self-administered digital cognitive assessments (SA-DCAs) offer...

Classification of tau status with machine learning models in amyloid‐positive cohorts

by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia

Abstract INTRODUCTION Although tau positron emission tomography (PET) imaging is effective for staging tau pathology, it is limited clinically by cost and availability. Machine learning models based on magnetic resonance imaging (MRI)– and amyloid PET–derived features...

Identifying the Factors Associated with Sexual Dissatisfaction in Spouse Caregivers of Persons with Dementia: The Importance of Conjugal Satisfaction

by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia

Dementia, Ahead of Print. Sexuality plays an important role for couples confronted with dementia and may support them to cope with the disease, to sustain the couple relationship and sustain a better experience of the caregiving situation. Nevertheless, the majority...

Refining our understanding of sleep impairment and connection to Alzheimer’s disease in preclinical models

by Clinical Neuropsychologist Online | Tuesday, July 28, 2026 | Dementia

Alzheimer’s &Dementia, Volume 22, Issue 8, August 2026. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | July 28, 2026 Neuro-Dementia Previous...

Associations of dementia polyexposure scores to Alzheimer’s disease endophenotypes in a diverse population

by Clinical Neuropsychologist Online | Tuesday, July 28, 2026 | Dementia

Abstract INTRODUCTION Dementia clinical risk scores (CRSs) provide accessible tools for identifying individuals at risk for Alzheimer’s disease (AD) and related dementias, yet their performance across diverse populations and relationships to AD endophenotypes...