Genetic evidence suggests a protective role of immunoglobulin M in Alzheimer’s disease

by Clinical Neuropsychologist Online | Monday, September 21, 2026 | Dementia

Abstract INTRODUCTION Immune dysfunction has been implicated in Alzheimer’s disease (AD), but the roles of specific immunoglobulin classes remain unclear. METHODS We integrated human genetics and plasma biomarker analyses to evaluate immunoglobulin G (IgG), IgA,...

Clinical modifiers of the association between type 1 diabetes and dementia incidence

by Clinical Neuropsychologist Online | Monday, September 21, 2026 | Dementia

Abstract INTRODUCTION Type 1 diabetes mellitus (T1DM) increases dementia risk. Understanding clinical modifiers of that effect could inform prevention. METHODS We analyzed data from All of Us. Participants were aged ≥50 years with T1DM (n = 5,442) or no diabetes...

Correction to “Human iPSC‐derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer’s disease model”

by Clinical Neuropsychologist Online | Monday, September 21, 2026 | Dementia

Alzheimer’s &Dementia, Volume 22, Issue 9, September 2026. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | September 21, 2026 Neuro-Dementia...

Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p‑tau181 levels in mild cognitive impairment

by Clinical Neuropsychologist Online | Monday, September 21, 2026 | Dementia

Abstract INTRODUCTION The role of complement in Alzheimer’s disease (AD) remains unclear, particularly regarding tau pathology and memory decline. METHODS In 123 mild cognitive impairment (MCI) participants from Alzheimer’s Disease Neuroimaging Initiative...

Divergent associations of estimated cardiorespiratory fitness with cognitive trajectories in Chinese and U.S. middle‐aged and older adults: A descriptive cross‐national comparison from CHARLS and HRS

by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia

Abstract INTRODUCTION The association between cardiorespiratory fitness (CRF) and cognition may differ across populations, but cross-cultural evidence remains limited. We explored whether estimated CRF (eCRF) shows divergent associations with cognitive trajectories in...

Retinal microvascular changes are related to indicators of glymphatic dysfunction and small vessel disease in frontotemporal dementia

by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia

Abstract INTRODUCTION Retinal vascular alterations have been associated with cerebral small vessel disease (SVD) in frontotemporal dementia (FTD), but their relationship with magnetic resonance imaging (MRI)-derived glymphatic-related diffusion markers remains...