by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION Synaptic dysfunction is an early feature of Alzheimer’s disease (AD) and proper localization of proteins involved in pre- and post-synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION A prognostic score (PS) summarizes a patient’s expected disease progression and can increase the statistical efficiency of clinical trials when included as an analysis covariate. METHODS We pooled patient data from observational studies and...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION There is a need for early, objective markers of Alzheimer’s disease (AD)-related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β-synuclein is elevated in the blood of adults with DS. This study evaluates the...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION Conventional cognitive instruments exhibit limited efficacy in detecting insidious cognitive decline in subjective cognitive decline (SCD) due to neural compensation. We hypothesized that auditory distraction during a visual memory task would...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION In semantic dementia (SD), no consistent prognostic factors for early care home (CH) admission or mortality have been identified, despite their potential utility in care management. METHODS Over a 31-year period, we collected sociodemographic,...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION Qualitative models of Alzheimer’s disease (AD) pathology often posit that amyloid accumulation follows a sigmoid curve, indicating that the rate of deposition wanes over time. Longitudinal positron emission tomography (PET) data now allow...
