by Clinical Neuropsychologist Online | Thursday, October 29, 2026 | Dementia
Abstract INTRODUCTION Early identification of amyloid-beta (Aβ) pathology is essential for timely intervention in Alzheimer’s disease (AD), as Aβ accumulation precedes clinical symptoms by years. METHODS We predicted positron emission tomography (PET) -defined...
by Clinical Neuropsychologist Online | Wednesday, October 28, 2026 | Dementia
Abstract INTRODUCTION Novel tools for absolute quantification of established and emerging fluid neuro-biomarkers are required to advance diagnostic studies and improve biological insights. METHODS We conducted an extensive analytical and clinical validation of the...
by Clinical Neuropsychologist Online | Wednesday, October 28, 2026 | Dementia
Abstract INTRODUCTION Hearing loss and loneliness are potentially modifiable risk factors for cognitive decline and dementia, but it remains unclear whether loneliness represents a causal pathway linking hearing loss to cognitive aging or whether these associations...
by Clinical Neuropsychologist Online | Wednesday, October 28, 2026 | Dementia
Abstract Social isolation and loneliness are distinct but overlapping dementia risk factors, though their underlying neurobiological mechanisms remain unclear. A systematic search identified 42 studies examining social isolation, loneliness, and neurobiological...
by Clinical Neuropsychologist Online | Wednesday, October 28, 2026 | Dementia
Abstract INTRODUCTION Real-world modifiers of lecanemab benefit in Alzheimer’s disease (AD) remain elusive. We examined associations between caregiver positivity and longitudinal outcomes in AD. METHODS This seven-center longitudinal study followed 127...
by Clinical Neuropsychologist Online | Wednesday, October 28, 2026 | Dementia
Abstract INTRODUCTION Age-related cognitive decline and Alzheimer’s disease (AD) are strongly influenced by lipid metabolism, yet how central and peripheral lipid profiles relate to disease risk before symptom onset remains unclear. METHODS We performed...
