Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

by Clinical Neuropsychologist | Monday, May 26, 2025 | Neuroscience

Nature Neuroscience, Published online: 26 May 2025; doi:10.1038/s41593-025-01964-9Rogers et al. show that psilocybin enhances fear extinction, suppresses fear neurons and recruits extinction neurons in the retrosplenial cortex in mice, providing evidence that its...

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration

by Clinical Neuropsychologist | Thursday, May 22, 2025 | Neuroscience

Nature Neuroscience, Published online: 22 May 2025; doi:10.1038/s41593-025-01955-wWhite matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment,...

Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment

by Clinical Neuropsychologist | Thursday, May 22, 2025 | Neuroscience

Nature Neuroscience, Published online: 22 May 2025; doi:10.1038/s41593-025-01929-yAging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white...

A dynamic and multimodal framework to define microglial states

by Clinical Neuropsychologist | Tuesday, May 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 May 2025; doi:10.1038/s41593-025-01978-3Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a robust...

Aging and injury drive neuronal senescence in the dorsal root ganglia

by Clinical Neuropsychologist | Wednesday, May 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 May 2025; doi:10.1038/s41593-025-01954-xThe authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain. If you do not see...

Activity-driven myelin sheath growth is mediated by mGluR5

by Clinical Neuropsychologist | Wednesday, May 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 May 2025; doi:10.1038/s41593-025-01956-9Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling...