Making the Brain Language Ready: A Journey of Discovery

by Clinical Neuropsychologist | Tuesday, November 4, 2025 | Neuroscience

CNS 2026 Q&A with Peter Hagoort From his days as an undergraduate student assistant at the Max Planck Institute for Psycholinguistics to his work now as Director of the Institute, Peter Hagoort has come full circle in his career, seeking to unlock the mechanisms...

Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences

by Clinical Neuropsychologist | Monday, November 3, 2025 | Neuroscience

Nature Neuroscience, Published online: 03 November 2025; doi:10.1038/s41593-025-02099-7Dominant coactivation patterns are primarily studied in resting-state fMRI. Here, the authors study the rest of the signal, which reveals ‘caricatured’ connectomes with improved...

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

by Clinical Neuropsychologist | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02096-wTDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment...

Specialized structure of neural population codes in parietal cortex outputs

by Clinical Neuropsychologist | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02095-xCortical neurons comprising an output pathway form a specialized population code that enhances the propagation of information to a downstream target, potentially improving the...

Dendritome mapping reveals the spatial organization of striatal neuron morphology

by Clinical Neuropsychologist | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02085-zThe authors mapped the dendritic morphology of thousands of striatal D1-type and D2-type medium spiny neurons in healthy and Huntington’s disease mouse brains, revealing dendritic...

Laser-engineered PRIME fiber for panoramic reconfigurable control of neural activity

by Clinical Neuropsychologist | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02106-xThe authors develop a neural probe with over 1,000 light emitters arranged along its length and circumference, enabling panoramic 3D optical stimulation across large brain volumes....