Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging

by Clinical Neuropsychologist | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02023-zHow reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and...

The brain drain puts aging myelin in deep trouble

by Clinical Neuropsychologist | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02028-8In this issue, Stamenkovic et al. describe deep in vivo imaging of the brain vasculature to document its evolution during aging, which identifies a unique vulnerability at the site of...

Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02032-yActivation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02027-9Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting...

Layer-specific changes in sensory cortex across the lifespan in mice and humans

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02013-1The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep layer...

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

by Clinical Neuropsychologist | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02039-5By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing mechanism that...